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Fertility Centre Prague, Czech Republic
LABORATORY METHODS PGT: Preimplantation genetic testing hero-image PGT: Preimplantation genetic testing hero-image
LABORATORY METHODS

PGT: Preimplantation genetic testing

Every parent's greatest wish is to have a healthy child. By determining the genetic makeup of embryos, we can detect problems in time. We then only transfer embryos that have a greater chance of producing a healthy baby to the uterus.

Genetic abnormalities are a common cause of early miscarriages in the first trimester of pregnancy. Preimplantation testing helps prevent these losses. There are three types of preimplantation testing - PGT-A, PGT-SR and PGT-M.

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Preimplantation genetic testing for aneuploidies (PGT-A) # ICON

Preimplantation genetic testing for aneuploidies (PGT-A)

Preimplantation genetic testing for aneuploidies (PGT-A) - formerly preimplantation genetic screening (PGS). Tests for chromosomal abnormalities before the transfer of the embryo to the uterus. The wrong number of chromosomes is one of the causes of the embryo’s failure to implant (nest) in the endometrium or miscarriage in the early stages of pregnancy.

 

Preimplantation genetic testing for structural chromosomal abnormalities (PGT-SR) # ICON

Preimplantation genetic testing for structural chromosomal abnormalities (PGT-SR)

The PGT-SR test is particularly recommended if one or both partners have a history of genetic disorders in the family. This test is used to rule out chromosome rearrangements (e.g. translocations) leading to miscarriages or the birth of a child with multiple developmental defects.

 

Preimplantation genetic testing for monogenic diseases (PGT-M) # ICON

Preimplantation genetic testing for monogenic diseases (PGT-M)

PGT-M (formerly known as PGD) is indicated for couples with a known risk of transmitting a serious genetic disease. PGT-M testing is performed prior to embryo transfer and is a method designed for couples with a genetic burden that minimises the risk of transmitting serious defects and hereditary diseases to their offspring.

 

SUCCESS OF PGT

PGT increases the chance of an embryo implanting in the uterus and reduces the likelihood of miscarriage

According to data from the USA, PGT has a very positive effect on the success of embryo implantation in a woman's uterus. However, there is a significant difference in the rate of success for clients over the age of 40.

PGT also significantly reduces the frequency of miscarriages, especially in women over the age of 40.

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How does PGT work? Icon

How does PGT work?

  • We wait for 120 hours after fertilisation, when the embryo has a greater number of cells.

  • We carefully separate one or more cells and analyse them.

  • The analysis is carried out using various methods – FISH (fluorescence in situ hybridisation) aCGH (microarray-based comparative genomic hybridisation), PCR (polymerase chain reaction).

  • The embryo is not damaged by this intervention and is frozen using vitrification. Once PGT results are available, it can be used for transfer.

  • We will recommend the best embryos for transfer to the uterus after evaluating the results.

When is this method indicated? section image

When is this method indicated?

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    In case of repeated miscarriages

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    If the mother is older

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    If chromosomal abnormalities are found in either of the partners.

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    If the couple has repeatedly undergone unsuccessful embryo transfers in IVF cycles.

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    Following treatment of oncological diseases associated with radiation or chemotherapy, etc.

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