KIR genes and HLA-C testing
KIR genes are genetic "switches" in the female immune system. Every embryo carries HLA-C antigens. KIR and HLA-C testing helps to reveal whether the embryo's surface antigens can activate the cells responsible for the proper implantation process in the uterus.
Otherwise, the body may react excessively to the embryo, which will act as a switch for the mother's immune system and either prevent the implantation process from starting at all or cause it to proceed incorrectly, resulting in a miscarriage.
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What is the principle behind KIR and HLA-C testing?
The test reveals whether a woman's immune system can help the embryo implant properly in the uterus or, conversely, block the implantation process. A mismatch between KIR genes and HLA-C antigens is referred to as immune incompatibility and can significantly reduce the chances of pregnancy.
More about laboratory methods-
In cases of repeated unsuccessful embryo transfers
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For couples who are unable to conceive despite having high-quality embryos
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After repeated miscarriages
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If preeclampsia, HELLP syndrome or foetal growth problems occurred in a previous pregnancy
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For patients who have undergone unsuccessful IVF with donated eggs
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If you want to rule out an immunological cause of infertility before treatment
How does the examination work?
1.
Discuss your and your partner's medical history and previous treatment with your doctor. Based on the available information, the doctor will recommend the necessary tests, including KIR genes and HLA-C testing.2.
The examination is performed from a routine collection of a small amount of the patient's blood.3.
You will receive the results within a few days, and your doctor will explain in detail what they mean for your further treatment.4.
Follow-up treatment involves the use of a white blood cell growth factor called filgrastim. This can influence the immune system's response to make it more receptive to the embryo.
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Sanakin®
Sanakin® (ACRS – Autologous Conditioned Serum Rich in Cytokines) is a modern laboratory method that uses the patient's own blood.
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ICSI
ICSI is the injection of sperm directly into an egg. This significantly increases the chance of fertilisation.
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EmbryoScope
We can increase the chances of pregnancy by selecting only the best quality embryos for transfer. We can identify these through continuous monitoring in EmbryoScope.
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PESA/MESA/TESE
In the absence of live sperm in the ejaculate, there is the possibility of obtaining sperm surgically from the epididymis (PESA or MESA) or testis (TESE).
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EmbryoGen / BlastGen
EmbryoGen and BlastGen are sequential culture media meticulously engineered to closely emulate the natural developmental progression of embryos.
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IVF with egg donation
If a woman cannot conceive and her partner's sperm are healthy, we use donor eggs fertilised with the partner's sperm.
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IVF using donor embryos
Donated eggs and donated sperm are used for in vitro fertilisation.
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IVF using donor sperm
For couples who cannot conceive naturally and the woman's eggs are healthy, we can use donor sperm from a suitable anonymous donor to fertilise the eggs.
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IVF using own eggs
We recommend IVF if the couple cannot conceive naturally.
More informationFree initial consultation
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